Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11180243 | 0.90 | TDP1 (0.73) | TDP1AKR1C3ALDH1A1POLBBRD4 | |
| SCHEMBL4521279 | 0.82 | TDP1 (0.64) | TDP1ALDH1A1POLBBRD4BRD2 | |
| SCHEMBL411204 | 0.81 | TDP1 (0.74) | TDP1ALDH1A1POLBBRD4BRD2 | |
| SCHEMBL11894277 | 0.78 | MEP1B (0.48) | TDP1ALDH1A1POLBMAPTHTT | |
| SCHEMBL11103811 | 0.76 | ALDH1A1 (0.74) | TDP1AKR1C3ALDH1A1TP53MAPT | |
| SCHEMBL11596502 | 0.74 | AKR1C3 (0.62) | TDP1AKR1C3ALDH1A1POLBHTT | |
| SCHEMBL1287405 | 0.74 | MPO (0.52) | ALDH1A1POLBHDAC1HDAC8HDAC6 | |
| SCHEMBL29123955 | 0.74 | MAPT (0.72) | TDP1AKR1C3ALDH1A1POLBTP53 | |
| SCHEMBL108588 | 0.73 | POLB (0.55) | ALDH1A1POLBTP53MAPTNPSR1 | |
| SCHEMBL11894500 | 0.73 | ALKBH2 (0.49) | ALDH1A1POLBNPSR1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047926-A2 | SULFONAMIDE-CONTAINING COMPOUNDS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-04-12 | — | — | WO | disclosed |