Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875147 | 0.89 | MEN1 (0.51) | MAPTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL12875146 | 0.82 | MEN1 (0.43) | FAAHSMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL12874915 | 0.82 | EPHX2 (0.52) | LMNASMN1; SMN2RAB9AKMT2AGAA | |
| SCHEMBL12875314 | 0.77 | KDM4E (0.47) | FAAHMEN1KMT2APOLBGAA | |
| SCHEMBL1147279 | 0.76 | MAPT (0.53) | FAAHMAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL1146747 | 0.75 | FAAH (0.50) | FAAHMAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL12875143 | 0.75 | CNR2 (0.49) | FAAHTP53GAA | |
| SCHEMBL12875690 | 0.75 | CHRNB2 (0.50) | MAPTSMN1; SMN2MEN1KMT2APKM | |
| SCHEMBL1147286 | 0.75 | MAPT (0.54) | FAAHMAPTLMNAOPRM1OPRD1 | |
| SCHEMBL1146884 | 0.73 | FAAH (0.50) | FAAHMAPTLMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012602-A1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-02-03 | — | — | WO | disclosed |