Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.52 |
| ▸ | NPY2R | P49146 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12874912 | 0.82 | FAAH (0.48) | KMT2ARAB9AALDH1A1LMNAGAA | |
| SCHEMBL12874947 | 0.77 | NPC1 (0.51) | KMT2ARAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12875143 | 0.75 | CNR2 (0.49) | EPHX2GAA | |
| SCHEMBL12875690 | 0.75 | CHRNB2 (0.50) | CYP2C9KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL12875147 | 0.74 | MEN1 (0.51) | NPY2RKMT2ARAB9AALDH1A1LMNA | |
| SCHEMBL1147359 | 0.74 | EPHX2 (0.52) | EPHX2NPY2RNAMPTRXFP1KMT2A | |
| SCHEMBL1147377 | 0.73 | EPHX2 (0.72) | EPHX2TDP1 | |
| SCHEMBL1147350 | 0.72 | KMT2A (0.53) | EPHX2NAMPTRXFP1KMT2ARAB9A | |
| SCHEMBL15058808 | 0.69 | RXFP1 (0.62) | EPHX2RXFP1CYP2C9CYP2C19HTR2B | |
| SCHEMBL15387509 | 0.68 | EPHX2 (0.70) | EPHX2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012602-A1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-02-03 | — | — | WO | disclosed |