Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | PANK3 | Q9H999 | 10/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875130 | 0.87 | PANK3 (0.59) | NPC1RAB9APANK3CNR2MAPT | |
| SCHEMBL12874915 | 0.77 | EPHX2 (0.52) | RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL1147470 | 0.76 | PANK3 (0.59) | NPC1RAB9APANK3CNR2MAPT | |
| SCHEMBL1147398 | 0.76 | NPC1 (0.61) | NPC1RAB9AFAAHPANK3MAPT | |
| Hydrochloric Acid SCHEMBL15387462 | 0.75 | NPC1 (0.60) | NPC1RAB9AFAAHPANK3MAPT | |
| SCHEMBL1147428 | 0.73 | PANK3 (0.64) | NPC1RAB9AFAAHPANK3MAPT | |
| SCHEMBL1160481 | 0.73 | EPHX2 (0.57) | NPC1RAB9AALDH1A1TRPV1 | |
| SCHEMBL12874912 | 0.73 | FAAH (0.48) | NPC1RAB9AFAAHMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1160745 | 0.73 | PANK3 (0.63) | NPC1RAB9AFAAHPANK3MAPT | |
| SCHEMBL12875314 | 0.72 | KDM4E (0.47) | FAAHALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012602-A1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-02-03 | — | — | WO | disclosed |