Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 6/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875711 | 0.91 | LIPE (0.43) | LIPECNR2CNR1 | |
| SCHEMBL12875714 | 0.89 | LIPE (0.42) | LIPEPKMPLA2G1BATG4BCNR2 | |
| SCHEMBL12875690 | 0.83 | CHRNB2 (0.50) | LIPEPKMPLA2G1BATG4BCNR2 | |
| SCHEMBL12874924 | 0.81 | MEN1 (0.45) | POLBALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL12875713 | 0.80 | LIPE (0.42) | LIPECNR2CNR1 | |
| SCHEMBL12875146 | 0.77 | MEN1 (0.43) | POLBALDH1A1MEN1KMT2AGAA | |
| SCHEMBL1147320 | 0.74 | LIPE (0.47) | LIPECNR2CYP2C9CHRNB2CHRNB4 | |
| SCHEMBL12875143 | 0.73 | CNR2 (0.49) | LIPECNR2CNR1GAA | |
| SCHEMBL15387727 | 0.69 | LIPE (0.45) | LIPECNR2CYP2C9CHRNB2CHRNB4 | |
| SCHEMBL11888832 | 0.68 | PKM (0.51) | PKMCHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012602-A1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-02-03 | — | — | WO | disclosed |