Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800661 | 0.87 | ADORA1 (0.47) | PRKCQADORA1MCL1L3MBTL1BTK | |
| SCHEMBL18800769 | 0.76 | ADORA2A (0.48) | ADORA1L3MBTL1BTKALDH1A1HSD17B10 | |
| SCHEMBL18800747 | 0.76 | KMT2A (0.46) | ADORA1L3MBTL1BTKALDH1A1KDM4E | |
| SCHEMBL18800471 | 0.75 | TNK2 (0.40) | PRKCQADORA1L3MBTL1BTKALDH1A1 | |
| SCHEMBL18800753 | 0.73 | BTK (0.49) | ADORA1BTK | |
| SCHEMBL18800775 | 0.73 | TNK2 (0.48) | ADORA1BTKKMT2AMAPTGAA | |
| SCHEMBL18800635 | 0.72 | BTK (0.48) | ADORA1BTK | |
| SCHEMBL18800492 | 0.72 | BTK (0.48) | ADORA1BTK | |
| SCHEMBL18800651 | 0.72 | BTK (0.43) | BTK | |
| SCHEMBL18800616 | 0.72 | BTK (0.47) | ADORA1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011019780-A1 | AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-17 | — | — | WO | disclosed |