Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800769 | 0.89 | ADORA2A (0.48) | ADORA1ALDH1A1MAPTTNK2BTK | |
| SCHEMBL18800747 | 0.89 | KMT2A (0.46) | ADORA1ALDH1A1MAPTTNK2BTK | |
| SCHEMBL18800753 | 0.88 | BTK (0.49) | ADORA1TNK2BTK | |
| SCHEMBL12875210 | 0.87 | PRKCQ (0.46) | ADORA1ALDH1A1HPGDSGAAMAPT | |
| SCHEMBL18800492 | 0.86 | BTK (0.48) | ADORA1TNK2BTK | |
| SCHEMBL18800616 | 0.85 | BTK (0.47) | ADORA1TNK2BTK | |
| SCHEMBL18800651 | 0.85 | BTK (0.43) | TNK2BTK | |
| SCHEMBL18800564 | 0.84 | BTK (0.47) | ALDH1A1MAPTTNK2BTK | |
| SCHEMBL18800775 | 0.84 | TNK2 (0.48) | ADORA1GAAMAPTTNK2BTK | |
| SCHEMBL18800748 | 0.83 | BTK (0.42) | GAAMAPTTNK2BTKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |