Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BMP1 | P13497 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287448 | 0.84 | CXCR3 (0.57) | POLBMEN1KMT2AALDH1A1TAS2R14 | |
| SCHEMBL1287293 | 0.82 | MEN1 (0.60) | POLBMEN1KMT2ATAS2R14CXCR3 | |
| SCHEMBL1287415 | 0.81 | TP53 (0.61) | POLBMEN1KMT2AALDH1A1TAS2R14 | |
| SCHEMBL1287414 | 0.79 | TAS2R14 (0.69) | POLBMEN1KMT2ATAS2R14CNR2 | |
| SCHEMBL2474708 | 0.76 | BACE1 (0.52) | POLBMEN1KMT2AALDH1A1TAS2R14 | |
| SCHEMBL1287330 | 0.75 | MEN1 (0.64) | POLBMEN1KMT2AALDH1A1TAS2R14 | |
| SCHEMBL1287514 | 0.74 | TAS2R14 (0.50) | ALDH1A1TAS2R14TP53GAAMAPT | |
| SCHEMBL22908331 | 0.74 | — | — | |
| SCHEMBL1287263 | 0.74 | POLB (0.69) | POLBMEN1KMT2ATAS2R14TP53 | |
| SCHEMBL1675487 | 0.74 | PSEN1 (0.46) | MEN1KMT2AALDH1A1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047926-A2 | SULFONAMIDE-CONTAINING COMPOUNDS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-04-12 | — | — | WO | disclosed |