Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.30 |
| ▸ | BRS3 | P32247 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198754 | 0.89 | ALDH1A1 (0.37) | L3MBTL1KLKB1ALDH1A1KDM4EEGLN1 | |
| SCHEMBL12875981 | 0.87 | KLKB1 (0.41) | DHODHALKBH1L3MBTL1KLKB1RAB9A | |
| SCHEMBL12875968 | 0.84 | L3MBTL1 (0.41) | DHODHALKBH1L3MBTL1KLKB1RAB9A | |
| SCHEMBL12876294 | 0.84 | RAB9A (0.36) | DHODHALKBH1L3MBTL1KLKB1RAB9A | |
| SCHEMBL12876201 | 0.83 | KLKB1 (0.40) | DHODHL3MBTL1KLKB1RAB9AALDH1A1 | |
| SCHEMBL12876300 | 0.81 | KLKB1 (0.36) | DHODHALKBH1L3MBTL1KLKB1RAB9A | |
| SCHEMBL12875908 | 0.80 | L3MBTL1 (0.39) | DHODHALKBH1L3MBTL1KLKB1RAB9A | |
| SCHEMBL12875895 | 0.80 | L3MBTL1 (0.39) | DHODHALKBH1L3MBTL1KLKB1RAB9A | |
| SCHEMBL12875802 | 0.80 | L3MBTL1 (0.39) | ALKBH1L3MBTL1KLKB1RAB9AALDH1A1 | |
| SCHEMBL12875995 | 0.78 | ALKBH1 (0.48) | ALKBH1L3MBTL1KLKB1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | PDE3B, PDE5A, PDE2A | DHODH 462/4885ALKBH1 1916/4885L3MBTL1 4726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.