Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.49 |
| ▸ | BRD2 | P25440 | 3/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | BRD1 | O95696 | 1/20 | 0.43 |
| ▸ | CCL2 | P13500 | 1/20 | 0.43 |
| ▸ | TAF1 | P21675 | 1/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1191859 | 1.00 | BRD4 (0.49) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL13400188 | 0.87 | BRD4 (0.49) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL1191498 | 0.87 | BRD4 (0.48) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL1191647 | 0.87 | BRD4 (0.48) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL14308375 | 0.81 | BRD4 (0.38) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL12876607 | 0.79 | BRD4 (0.58) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL12643367 | 0.79 | BRD4 (0.41) | BRD4MAPTLMNA | |
| SCHEMBL13585256 | 0.79 | BRD4 (0.41) | BRD4MAPTLMNA | |
| SCHEMBL4350016 | 0.79 | L3MBTL1 (0.56) | BRD4BRD2BRD3BRDTMAPT | |
| SCHEMBL4350013 | 0.79 | L3MBTL1 (0.56) | BRD4BRD2BRD3BRDTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888375-B2 | Pyridinone diketo acids: inhibitors of HIV replication | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888375-B2 | Pyridinone diketo acids: inhibitors of HIV replication | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC (US) | 2011-02-15 | — | — | US | disclosed |
| US-20100092427-A1 | Pyridinone Diketo Acids: Inhibitors of HIV Replication in Combination Therapy | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) | 2010-04-15 | — | — | US | disclosed |
| US-20100092427-A1 | Pyridinone Diketo Acids: Inhibitors of HIV Replication in Combination Therapy | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) | 2010-04-15 | — | — | US | disclosed |
| US-20080020010-A1 | Pyridinone diketo acids: inhibitors of HIV replication | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080020010-A1 | Pyridinone diketo acids: inhibitors of HIV replication | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2008-01-24 | — | — | US | disclosed |
| WO-2008010953-A2 | PYRIDINONE DIKETO ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100092427-A1 | Pyridinone Diketo Acids: Inhibitors of HIV Replication in Combination Therapy | TKT, DHFR, DTYMK | BRD4 2605/4885BRD2 3731/4885BRD3 3270/4885 |
| US-20080020010-A1 | Pyridinone diketo acids: inhibitors of HIV replication | DCK, PDXK, DTYMK | BRD4 1557/4885BRD2 2339/4885BRD3 1580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.