Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.53 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.46 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28804512 | 0.89 | TSHR (0.59) | WDR5TSHRLDHACYP3A4NR4A1 | |
| SCHEMBL26054329 | 0.82 | TSHR (0.55) | WDR5TSHRLDHACYP3A4NCEH1 | |
| SCHEMBL1287810 | 0.82 | NCEH1 (0.57) | TSHRCYP3A4NR4A2NCEH1ALDH1A1 | |
| SCHEMBL5836018 | 0.80 | CYP3A4 (0.59) | TSHRCYP3A4NR4A1NR4A2NR4A3 | |
| SCHEMBL9558553 | 0.80 | CYP3A4 (0.59) | WDR5TSHRLDHACYP3A4ALDH1A1 | |
| SCHEMBL9827265 | 0.80 | CYP3A4 (0.59) | TSHRCYP3A4NR4A1NR4A2NR4A3 | |
| SCHEMBL17060428 | 0.79 | TSHR (0.55) | WDR5TSHRLDHACYP3A4NCEH1 | |
| SCHEMBL5837648 | 0.79 | CYP3A4 (0.57) | TSHRCYP3A4NR4A1NR4A2NR4A3 | |
| SCHEMBL17060426 | 0.79 | TSHR (0.55) | WDR5TSHRLDHACYP3A4NCEH1 | |
| SCHEMBL28275810 | 0.78 | PTPN1 (0.54) | TSHRCYP3A4ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402026-A | Molecular isomerization method based on perovskite nanocrystalline sensitization | 中国科学院大连化学物理研究所 | 2024-01-16 | — | — | CN | claimed |
| JP-7326045-A | — | — | None | — | — | JP | disclosed |
| CN-117402026-A | Molecular isomerization method based on perovskite nanocrystalline sensitization | 中国科学院大连化学物理研究所 | 2024-01-16 | — | — | CN | disclosed |
| US-10308633-B2 | Process for making M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2019-06-04 | — | — | US | disclosed |
| US-9708273-B2 | Aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160229813-A1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2016-08-11 | — | — | US | disclosed |
| US-9260418-B2 | Pyranyl aryl methyl benzoquinolinone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2016-02-16 | — | — | US | disclosed |
| EP-2624697-B1 | DIHYDROBENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2015-11-25 | — | — | EP | disclosed |
| EP-2915812-A1 | Pyranyl aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators | Merck Sharp & Dohme Corp. (US) | 2015-09-09 | — | — | EP | disclosed |
| CN-102480964-B | Pyranyl aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME | 2015-07-08 | — | — | CN | disclosed |
| WO-2012047702-A1 | DIHYDROBENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-12 | — | — | WO | disclosed |
| CN-102292323-A | Aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators | — | 2011-12-21 | — | — | CN | disclosed |
| US-20110224198-A1 | ARYL METHYL BENZOQUINAZOLININE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME LLC | 2011-09-15 | — | — | US | disclosed |
| EP-2358686-A1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2011084371-A1 | AMINOBENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011025851-A1 | PYRANYL ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-03-03 | — | — | WO | disclosed |
| US-20100228048-A1 | PROCESS FOR PREPARING SUBSTITUTED AROMATIC CARBOXYLIC ACIDS | PERKINELMER HEALTH SCIENCES, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100228048-A1 | PROCESS FOR PREPARING SUBSTITUTED AROMATIC CARBOXYLIC ACIDS | PERKINELMER HEALTH SCIENCES, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| WO-2010059773-A1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-05-27 | — | — | WO | disclosed |
| JP-H07326045-A | MAGNETIC RECORDING MEDIUM | SONY CORP | 1995-12-12 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308633-B2 | Process for making M1 receptor positive allosteric modulators | CHRM1, CHRM4, CHRM2 | WDR5 1726/4885TSHR 399/4885LDHA 4831/4885 |
| US-20110224198-A1 | ARYL METHYL BENZOQUINAZOLININE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, OPRL1, CHRM2 | WDR5 1357/4885TSHR 632/4885LDHA 4831/4885 |
| US-20100228048-A1 | PROCESS FOR PREPARING SUBSTITUTED AROMATIC CARBOXYLIC ACIDS | PAH, HAO2, DDC | WDR5 1661/4885TSHR 4202/4885LDHA 727/4885 |
| US-20160229813-A1 | ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, OPRL1, OPRM1 | WDR5 1566/4885TSHR 587/4885LDHA 4730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.