Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TK1 | P04183 | 3/20 | 0.34 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.33 |
| ▸ | TOP2A | P11388 | 3/20 | 0.33 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.33 |
| ▸ | P2RY6 | Q15077 | 3/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALB | P02768 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.32 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | POLG | P54098 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12885705 | 0.86 | ADRB1 (0.43) | POLBTK1CACNA1FLMNAALB | |
| SCHEMBL23316644 | 0.81 | POLB (0.40) | POLBP2RY2P2RY4P2RY6CACNA1F | |
| SCHEMBL13036648 | 0.78 | POLB (0.50) | POLBP2RY2P2RY4P2RY6CACNA1F | |
| SCHEMBL846006 | 0.77 | LMNA (0.53) | POLBTK1P2RY2P2RY4P2RY6 | |
| SCHEMBL13036663 | 0.73 | POLB (0.46) | POLBP2RY2P2RY4P2RY6CACNA1F | |
| SCHEMBL25082481 | 0.73 | LMNA (0.56) | POLBP2RY2P2RY4P2RY6CACNA1F | |
| SCHEMBL13036646 | 0.73 | LMNA (0.53) | POLBP2RY2P2RY4P2RY6CACNA1F | |
| SCHEMBL23200453 | 0.72 | POLB (0.51) | POLBP2RY2P2RY4P2RY6CACNA1F | |
| SCHEMBL25456568 | 0.72 | POLB (0.67) | POLBP2RY2P2RY4P2RY6CACNA1F | |
| SCHEMBL66763 | 0.72 | POLB (0.51) | POLBP2RY2P2RY4P2RY6CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888367-B2 | reverse transcriptase mutants which allow an obligate chain terminating nucleoside- or nucleotide phosphate to be excised from the nascent DNA strand by ATP- or pyrophosphate-mediated excision | MEDIVIR AB (SE) | 2011-02-15 | — | — | US | disclosed |
| US-20080221140-A1 | 1-[2',3' -Dideoxy-3' C-(Hydroxymethyl) - Beta-D-Erythro-Pentofuranosyl] Cytosine Derivatives as Hiv | MEDIVIR AB (SE) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221140-A1 | 1-[2',3' -Dideoxy-3' C-(Hydroxymethyl) - Beta-D-Erythro-Pentofuranosyl] Cytosine Derivatives as Hiv | NUDT1, TYMP, DPYD | POLB 14/4885TK1 24/4885P2RY2 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.