Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12890783 | 0.83 | CTSS (0.40) | MGLLBACE1HDAC4HDAC1 | |
| SCHEMBL12890782 | 0.79 | LTA4H (0.43) | LTA4HBACE1SYK | |
| SCHEMBL207904 | 0.79 | PDK1 (0.47) | RAB9AHDAC4HDAC1 | |
| SCHEMBL12890779 | 0.76 | CTSS (0.41) | BACE1HDAC4HDAC1 | |
| SCHEMBL13785635 | 0.76 | CTSK (0.41) | RAB9AHDAC4HDAC1 | |
| SCHEMBL3785111 | 0.76 | CTSK (0.41) | RAB9AHDAC4HDAC1 | |
| SCHEMBL3785113 | 0.76 | CTSK (0.41) | RAB9AHDAC4HDAC1 | |
| SCHEMBL208846 | 0.76 | SIRT2 (0.38) | MGLLHDAC4HDAC1 | |
| SCHEMBL14628031 | 0.75 | MAPT (0.50) | SYKHDAC1 | |
| SCHEMBL14628421 | 0.75 | MAPT (0.50) | SYKHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893020-B2 | can be coadministered with antimicrobial agents for treatment of infections caused by drug resistant bacteria; 2-Amino-N-{4-Amino-1-[-3-phenyl-1-(R)-(quinolin-3-ylcarbomoyl)-propylcarbamoyl]-butyl}succinamic acid; 2,5-Diamino-pentanoic acid [3-phenyl-1-(R)-(4-phenyl-thiazol-2-ylcarbamoyl)-propyl]-amide | MPEX PHARMACEUTICALS, INC. (US) | 2011-02-22 | — | — | US | disclosed |