Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12895521 | 0.97 | ALDH1A1 (0.42) | KDM4EALDH1A1RAB9AKCNA5L3MBTL1 | |
| SCHEMBL12895522 | 0.97 | KDM4E (0.43) | KDM4EALDH1A1RAB9AKCNA5L3MBTL1 | |
| SCHEMBL1209445 | 0.90 | ALDH1A1 (0.44) | KDM4EALDH1A1RAB9AL3MBTL1TP53 | |
| SCHEMBL12895686 | 0.87 | L3MBTL1 (0.50) | KDM4EALDH1A1RAB9AL3MBTL1TP53 | |
| SCHEMBL1207507 | 0.87 | ALDH1A1 (0.44) | KDM4EALDH1A1RAB9AL3MBTL1TP53 | |
| SCHEMBL1208309 | 0.87 | ALDH1A1 (0.46) | KDM4EALDH1A1RAB9AL3MBTL1TP53 | |
| SCHEMBL12895523 | 0.85 | RORC (0.40) | KDM4EALDH1A1RAB9ATNIKTSHR | |
| SCHEMBL14293237 | 0.85 | KDM4E (0.42) | KDM4EALDH1A1RAB9AADRB3KCNH2 | |
| SCHEMBL12895472 | 0.84 | ALDH1A1 (0.39) | KDM4EALDH1A1RAB9AL3MBTL1TSHR | |
| SCHEMBL14293203 | 0.84 | ALDH1A1 (0.39) | KDM4EALDH1A1RAB9AKCNA5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | NYCOMED GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | BAX, BCL2, BAD | KDM4E 2054/4885ALDH1A1 316/4885RAB9A 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.