⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042941 | 0.80 | — | — | |
| SCHEMBL2159361 | 0.80 | — | — | |
| SCHEMBL5451544 | 0.78 | — | — | |
| SCHEMBL1289844 | 0.73 | — | — | |
| SCHEMBL1289842 | 0.73 | — | — | |
| SCHEMBL5133637 | 0.72 | ALOX15 (0.46) | — | |
| SCHEMBL1289765 | 0.71 | — | — | |
| SCHEMBL97757 | 0.71 | — | — | |
| SCHEMBL293079 | 0.69 | CA1 (0.39) | — | |
| SCHEMBL2680479 | 0.69 | ECE1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880147-A | Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use | SANKYO COMPANY, LIMITED (JP) | 1999-03-09 | — | — | US | claimed |
| US-9168255-B2 | Quinazoline compounds as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20150250789-A1 | QUINAZOLINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. | 2015-09-10 | — | — | US | disclosed |
| US-9045435-B2 | Quinazoline compounds as sodium channel blockers | PURDUE PHARMA, L.P. (US) | 2015-06-02 | — | — | US | disclosed |
| EP-2625169-B1 | QUINAZOLINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA LP (US) | 2015-03-25 | — | — | EP | disclosed |
| US-20130289044-A1 | Quinazoline Compounds as Sodium Channel Blockers | PURDUE PHARMA L.P. (US) | 2013-10-31 | — | — | US | disclosed |
| EP-2625169-A1 | QUINAZOLINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS | Purdue Pharma L.P. (US) | 2013-08-14 | — | — | EP | disclosed |
| CN-103168033-A | Quinazoline compounds as sodium channel blockers | PURDUE PHARMA LP | 2013-06-19 | — | — | CN | disclosed |
| WO-2012046132-A1 | QUINAZOLINE COMPOUNDS AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2012-04-12 | — | — | WO | disclosed |
| US-6369101-B1 | Therapeutic method to treat herpes virus infection | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2002-04-09 | — | — | US | disclosed |
| WO-1998034603-A1 | USE OF BETULIN AND ANALOGS THEREOF TO TREAT HERPESVIRUS INFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1998-08-13 | — | — | WO | disclosed |
| CN-1102643-A | Substituted derivatives of diaminophthalimide | CIBA GEIGY AG (CH) | 1995-05-17 | — | — | CN | disclosed |
| US-5342547-A | Treating surface with indole compound to prevent attachment | MARINE BIOTECHNOLOGY INSTITUTE CO., LTD. (JP) | 1994-08-30 | — | — | US | disclosed |
| EP-0579819-A1 | NOVEL PYRIDONE DERIVATIVES, PREPARATION METHOD THEREFOR, NOVEL INTERMEDIATES THEREBY OBTAINED, THEIR USE AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1994-01-26 | — | — | EP | disclosed |
| WO-1993016049-A1 | NOVEL PYRIDONE DERIVATIVES, PREPARATION METHOD THEREFOR, NOVEL INTERMEDIATES THEREBY OBTAINED, THEIR USE AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL-UCLAF (FR) | 1993-08-19 | — | — | WO | disclosed |