Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.50 |
| ▸ | NPC1 | O15118 | 11/20 | 0.50 |
| ▸ | RAB9A | P51151 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12898282 | 0.82 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9AMAPTMEN1 | |
| SCHEMBL12898258 | 0.81 | SMN1; SMN2 (0.67) | SHMT2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL12898271 | 0.80 | TSHR (0.49) | SMN1; SMN2NPC1RAB9AMAPTMEN1 | |
| SCHEMBL12898269 | 0.79 | TRPV1 (0.44) | SMN1; SMN2NPC1RAB9AMAPTMEN1 | |
| SCHEMBL12898265 | 0.79 | FPR2 (0.44) | SMN1; SMN2NPC1RAB9AMAPTMEN1 | |
| SCHEMBL12898255 | 0.79 | PPIA (0.51) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL12898230 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AMAPTMEN1 | |
| SCHEMBL12898251 | 0.78 | PPIF (0.52) | SMN1; SMN2NPC1RAB9AMAPTMEN1 | |
| SCHEMBL1269344 | 0.78 | SHMT2 (0.53) | SHMT2SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL12898263 | 0.76 | MAPK1 (0.42) | SMN1; SMN2NPC1RAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039893-A1 | GSK-3BETA INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-02-17 | — | — | US | disclosed |
| US-20110039893-A1 | GSK-3BETA INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039893-A1 | GSK-3BETA INHIBITOR | GSK3B, GSK3A, GSKIP | SHMT2 433/4885SMN1; SMN2 865/4885NPC1 1656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.