Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 11/20 | 0.53 |
| ▸ | RAB9A | P51151 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12898229 | 0.80 | MAPT (0.77) | SMN1; SMN2MAPTMEN1KMT2APOLB | |
| SCHEMBL12898256 | 0.79 | SHMT2 (0.52) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL12898234 | 0.78 | F10 (0.50) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL12898221 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL12898237 | 0.77 | GAA (0.54) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL12898233 | 0.75 | MAPK1 (0.48) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL11117922 | 0.74 | LMNA (0.63) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL12898240 | 0.73 | HPGD (0.60) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL12898245 | 0.73 | RAB9A (0.51) | SMN1; SMN2LMNANPC1RAB9AMAPT | |
| SCHEMBL12898236 | 0.72 | USP2 (0.50) | SMN1; SMN2LMNAMAPTMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039893-A1 | GSK-3BETA INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-02-17 | — | — | US | disclosed |
| US-20110039893-A1 | GSK-3BETA INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039893-A1 | GSK-3BETA INHIBITOR | GSK3B, GSK3A, GSKIP | SMN1; SMN2 865/4885LMNA 1199/4885NPC1 1656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.