Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12900110 | 0.86 | RAB9A (0.52) | MEN1KMT2AALDH1A1POLBRAB9A | |
| SCHEMBL12900086 | 0.78 | HCAR2 (0.53) | MCL1MAPK8MEN1KMT2AALDH1A1 | |
| SCHEMBL12900106 | 0.75 | HSD17B1 (0.52) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL12900108 | 0.75 | SERPINE1 (0.53) | MCL1MEN1KMT2AALDH1A1POLB | |
| SCHEMBL6451894 | 0.75 | HCAR2 (0.52) | MAPK8HDAC2MEN1KMT2AALDH1A1 | |
| SCHEMBL12900109 | 0.74 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1POLBRAB9A | |
| SCHEMBL30838469 | 0.72 | MCL1 (0.66) | MCL1MAPK8GSK3BMEN1KMT2A | |
| SCHEMBL420345 | 0.70 | SERPINE1 (0.69) | MCL1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL418849 | 0.69 | SERPINE1 (0.67) | MCL1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12700385 | 0.69 | NPC1 (0.74) | MAPK8MEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028462-A1 | Niacin Receptor Agonists, compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2011-02-03 | — | — | US | disclosed |
| US-20110028462-A1 | Niacin Receptor Agonists, compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2011-02-03 | — | — | US | disclosed |
| WO-2007035478-A2 | NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028462-A1 | Niacin Receptor Agonists, compositions Containing Such Compounds and Methods of Treatment | LDLR, APOB, FFAR1 | MCL1 4559/4885MAPK8 2419/4885HDAC1 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.