Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 1/20 | 0.50 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12900093 | 0.94 | NPC1 (0.49) | FABP3FABP4FABP5NPC1MAPT | |
| SCHEMBL12900103 | 0.82 | FABP3 (0.53) | FABP3FABP4FABP5NPC1MAPT | |
| SCHEMBL12900092 | 0.80 | MAPT (0.48) | MAPTMEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL12900094 | 0.78 | HCAR2 (0.51) | NPC1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14566435 | 0.77 | L3MBTL1 (0.46) | NPC1MAPTMEN1KMT2ATP53 | |
| SCHEMBL12900100 | 0.76 | HDAC6 (0.55) | FABP3FABP4FABP5NPC1MAPT | |
| SCHEMBL6475383 | 0.75 | FABP4 (0.65) | FABP3FABP4FABP5NPC1MAPT | |
| SCHEMBL2274223 | 0.74 | ALDH1A1 (0.53) | FABP3FABP4FABP5NPC1MAPT | |
| SCHEMBL12900109 | 0.74 | ALDH1A1 (0.49) | FABP3FABP4FABP5NPC1MAPT | |
| SCHEMBL12900083 | 0.72 | GFER (0.48) | NPC1MAPTMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028462-A1 | Niacin Receptor Agonists, compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2011-02-03 | — | — | US | disclosed |
| US-20110028462-A1 | Niacin Receptor Agonists, compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2011-02-03 | — | — | US | disclosed |
| WO-2007035478-A2 | NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028462-A1 | Niacin Receptor Agonists, compositions Containing Such Compounds and Methods of Treatment | LDLR, APOB, FFAR1 | FABP3 136/4885FABP4 282/4885FABP5 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.