Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.79 |
| ▸ | OPRD1 known ✓ | P41143 | 6/20 | 0.79 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.79 |
| ▸ | MRGPRX2 | Q96LB1 | 5/20 | 0.79 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.79 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.79 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL12905622 | 0.94 | OPRD1 (0.70) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12905618 | 0.94 | OPRM1 (0.73) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12905894 | 0.94 | OPRM1 (0.70) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12905612 | 0.92 | OPRM1 (0.67) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12905630 | 0.91 | OPRM1 (0.71) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12905674 | 0.90 | OPRM1 (0.64) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12905626 | 0.90 | OPRM1 (0.69) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12905616 | 0.90 | OPRM1 (0.66) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12905647 | 0.89 | OPRM1 (0.63) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 | |
| Codeine SCHEMBL12906851 | 0.89 | OPRM1 (0.62) | OPRM1OPRD1MRGPRX2OPRK1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872013-B2 | Preparation and utility of opioid analgesics | AUSPEX PHARMACEUTICALS, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20080045558-A1 | PREPARATION AND UTILITY OF OPIOID ANALGESICS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045558-A1 | PREPARATION AND UTILITY OF OPIOID ANALGESICS | OPRM1, OPRK1, OPRL1 | OPRM1 1/4885OPRD1 4/4885OPRK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.