Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907210 | 0.85 | JAK2 (0.60) | PDPK1JAK2SGK1GSK3BCDK1 | |
| SCHEMBL12907465 | 0.82 | MAP2K4 (0.55) | PDPK1FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL14397096 | 0.79 | PDPK1 (0.53) | PDPK1FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL12907457 | 0.78 | JAK2 (0.67) | PDPK1FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL12907184 | 0.77 | JAK2 (0.62) | PDPK1JAK2GSK3BCDK1CDK2 | |
| SCHEMBL12907451 | 0.76 | FGFR1 (0.70) | PDPK1FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL12907438 | 0.74 | GSK3B (0.54) | PDPK1FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL12907468 | 0.74 | GSK3B (0.54) | PDPK1FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL12907422 | 0.73 | GSK3B (0.55) | PDPK1FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL8348438 | 0.73 | KIF11 (0.47) | FGFR1MEN1KMT2AGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |