Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | NT5C2 | P49902 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Purine SCHEMBL28164598 | 0.87 | ALDH1A1 (0.44) | CDK2KDM4EALDH1A1HSD17B10CYP3A4 | |
| Purine SCHEMBL30862524 | 0.87 | — | — | |
| Purine SCHEMBL6421380 | 0.87 | ALDH1A1 (0.47) | CDK2KDM4EALDH1A1HTTHSD17B10 | |
| Purine SCHEMBL29365913 | 0.87 | — | — | |
| Purine SCHEMBL2120554 | 0.87 | ALDH1A1 (0.47) | CDK2KDM4EALDH1A1HTTHSD17B10 | |
| Purine SCHEMBL29703771 | 0.87 | ALDH1A1 (0.47) | CDK2KDM4EALDH1A1HTTHSD17B10 | |
| Purine SCHEMBL3158 | 0.87 | — | — | |
| Purine SCHEMBL18011849 | 0.86 | CDK2 (0.42) | CDK2KDM4EALDH1A1HPGDTSHR | |
| Purine SCHEMBL7787140 | 0.85 | ALDH1A1 (0.45) | CDK2KDM4EALDH1A1HTTHSD17B10 | |
| Purine SCHEMBL31628309 | 0.85 | ALDH1A1 (0.45) | CDK2KDM4EALDH1A1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269778-A1 | NOVEL DIPHENYL PURINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2011-11-03 | — | — | US | claimed |
| WO-2010040806-A1 | NOVEL DIPHENYL PURINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-04-15 | — | — | WO | claimed |
| US-9458160-B2 | Peripherally restricted diphenyl purine derivatives | RESEARCH TRIANGLE INSTITUTE (US) | 2016-10-04 | — | — | US | disclosed |
| US-9187480-B2 | Peripherally restricted diphenyl purine derivatives | RESEARCH TRIANGLE INSTITUTE (US) | 2015-11-17 | — | — | US | disclosed |
| US-20110269778-A1 | NOVEL DIPHENYL PURINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2011-11-03 | — | — | US | disclosed |
| WO-2010040806-A1 | NOVEL DIPHENYL PURINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269778-A1 | NOVEL DIPHENYL PURINE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA5, CHRNA6, P2RX6 | ATM 2282/4885CDK2 1183/4885KDM4E 2332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.