SCHEMBL129294

SCHEMBL129294

CS(=O)(=O)Nc1ccc(-c2csc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)n2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CASR P41180 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL128115 0.99 CASR (0.98) CASR
SCHEMBL128927 0.91 CASR (0.83) CASR
Hydrochloric Acid SCHEMBL125565 0.90 CASR (0.82) CASR
SCHEMBL170257 0.90 CASR (0.85) CASR
SCHEMBL172222 0.90 CASR (1.00) CASR
SCHEMBL127686 0.90 CASR (0.81) CASR
SCHEMBL127866 0.89 CASR (0.89) CASR
Hydrochloric Acid SCHEMBL128247 0.89 CASR (0.98) CASR
Hydrochloric Acid SCHEMBL128875 0.88 CASR (0.87) CASR
SCHEMBL125231 0.88 CASR (0.90) CASR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110144102-A1 CALCIMIMETIC COMPOUND FOR USE IN THE TREATMENT OF EPITHELIAL INJURY AMGEN INC. 2011-06-16 US claimed
EP-2139462-A2 CALCIMIMETIC COMPOUNDS FOR USE IN THE TREATMENT OF BOWEL DISORDERS Amgen Inc. (US) 2010-01-06 EP claimed
EP-2037736-A1 METHODS FOR TREATING CYSTIC KIDNEY DISEASES Indiana University Research and Technology Corporation (US) 2009-03-25 EP claimed
US-20090018135-A1 Methods of treating bowel disorders AMGEN INC. (US) 2009-01-15 US claimed
EP-2010150-A2 STABLE EMULSION FORMULATIONS Amgen Inc. (US) 2009-01-07 EP claimed
WO-2008121386-A2 CALCIMIMETIC COMPOUNDS FOR USE IN THE TREATMENT OF BOWEL DISORDERS AMGEN INC. (US) 2008-10-09 WO claimed
US-20080027052-A1 METHODS FOR TREATING CYSTIC KIDNEY DISEASE INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2008-01-31 US claimed
WO-2008008650-A1 METHODS FOR TREATING CYSTIC KIDNEY DISEASES INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2008-01-17 WO claimed
WO-2007124465-A2 STABLE EMULSION FORMULATIONS AMGEN INC. (US) 2007-11-01 WO claimed
US-20070249520-A1 STABLE EMULSION FORMULATIONS AMGEN INC. (US) 2007-10-25 US claimed
US-8779004-B2 Stable emulsion formulations AMGEN, INC. (US) 2014-07-15 US disclosed
US-8609655-B2 Calcimimetic compound for use in the treatment of epithelial injury AMGEN INC. (US) 2013-12-17 US disclosed
US-20120283255-A1 UREA DERIVATIVES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR GALAPAGOS SASU (FR) 2012-11-08 US disclosed
US-20120283255-A1 UREA DERIVATIVES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR GALAPAGOS SASU (FR) 2012-11-08 US disclosed
US-20120232158-A1 METHODS OF TREATING HYPERACIDIC DISORDERS YALE UNIVERISTY 2012-09-13 US disclosed
EP-2010150-A2 STABLE EMULSION FORMULATIONS Amgen Inc. (US) 2009-01-07 EP disclosed
US-20080027052-A1 METHODS FOR TREATING CYSTIC KIDNEY DISEASE INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2008-01-31 US disclosed
WO-2008008650-A1 METHODS FOR TREATING CYSTIC KIDNEY DISEASES INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2008-01-17 WO disclosed
WO-2007124465-A2 STABLE EMULSION FORMULATIONS AMGEN INC. (US) 2007-11-01 WO disclosed
US-20070249520-A1 STABLE EMULSION FORMULATIONS AMGEN INC. (US) 2007-10-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120232158-A1 METHODS OF TREATING HYPERACIDIC DISORDERS HRH2, GRPR, SLC10A2 CASR 8/4885
US-20090018135-A1 Methods of treating bowel disorders SLC10A2, FABP2, ALPI CASR 224/4885
US-20080027052-A1 METHODS FOR TREATING CYSTIC KIDNEY DISEASE PKD2, PKD1, REN CASR 14/4885
US-20120283255-A1 UREA DERIVATIVES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR UTS2R, UGP2, SLC14A1 CASR 4125/4885
US-20070249520-A1 STABLE EMULSION FORMULATIONS CALCR, CALCB, CALCRL CASR 153/4885
US-20110144102-A1 CALCIMIMETIC COMPOUND FOR USE IN THE TREATMENT OF EPITHELIAL INJURY HIF1AN, HIF1A, CASR CASR 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.