Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.61 |
| ▸ | PGR | P06401 | 3/20 | 0.55 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.53 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.51 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.49 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | BRD1 | O95696 | 1/20 | 0.48 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12945230 | 0.86 | KEAP1 (0.60) | KEAP1NFE2L2PGRFFAR4GAA | |
| SCHEMBL28655832 | 0.81 | KEAP1 (0.50) | KEAP1 | |
| SCHEMBL3555853 | 0.79 | KEAP1 (0.56) | KEAP1NFE2L2PGRGLO1SLC40A1 | |
| SCHEMBL3560551 | 0.78 | KEAP1 (0.54) | KEAP1NFE2L2PGRGLO1SLC40A1 | |
| SCHEMBL3557703 | 0.77 | KEAP1 (0.53) | KEAP1NFE2L2PGRGLO1SLC40A1 | |
| SCHEMBL8419064 | 0.77 | LMNA (0.59) | KEAP1NFE2L2GAA | |
| SCHEMBL30026801 | 0.77 | LMNA (0.59) | KEAP1NFE2L2GAA | |
| SCHEMBL17388819 | 0.77 | PTGDR2 (0.57) | KEAP1NFE2L2PGRGLO1SLC40A1 | |
| SCHEMBL28389707 | 0.77 | FFAR4 (0.60) | KEAP1NFE2L2FFAR4TRIM24BRPF1 | |
| SCHEMBL12945620 | 0.76 | ALDH1A1 (0.45) | KEAP1NFE2L2PGRFFAR4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009059-A2 | METHOD OF TREATING OR PREVENTING CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-01-20 | — | — | WO | disclosed |