Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12945874 | 0.88 | ADAM17 (0.62) | ADAM17MAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12945694 | 0.80 | ALDH1A1 (0.44) | MAPTALDH1A1HTTPKMSMN1; SMN2 | |
| SCHEMBL20750037 | 0.78 | DDAH1 (0.51) | MAPTRAB9AALDH1A1HTTPKM | |
| SCHEMBL25773657 | 0.78 | ADAM17 (0.70) | ADAM17MAPTRAB9AALDH1A1HTT | |
| SCHEMBL19194944 | 0.78 | GAA (0.59) | ADAM17MAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL16566170 | 0.77 | ALDH1A1 (0.50) | ADAM17MAPTALDH1A1HTTTDP1 | |
| SCHEMBL18469647 | 0.75 | ALDH1A1 (0.40) | MAPTALDH1A1HTTPKMSMN1; SMN2 | |
| SCHEMBL16681934 | 0.74 | ALDH1A1 (0.47) | MAPTRAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL13057575 | 0.74 | ADAM17 (0.50) | ADAM17MAPTRAB9AALDH1A1HTT | |
| SCHEMBL13057572 | 0.74 | GAA (0.52) | ADAM17MAPTRAB9AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9463252-B2 | Auristatin drug linker conjugates | SEATTLE GENETICS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20140050746-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-20110020343-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110020343-A1 | AURISTATIN DRUG LINKER CONJUGATES | AURKA, AURKC, AURKB | ADAM17 294/4885MAPT 686/4885RAB9A 2870/4885 |
| US-20140050746-A1 | AURISTATIN DRUG LINKER CONJUGATES | AURKA, AURKC, AURKB | ADAM17 294/4885MAPT 686/4885RAB9A 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.