Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 11/20 | 0.46 |
| ▸ | FAAH | O00519 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208726 | 0.86 | HTT (0.55) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 | |
| SCHEMBL17235983 | 0.83 | CYP1A2 (0.57) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 | |
| SCHEMBL17208725 | 0.83 | DDAH1 (0.53) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 | |
| SCHEMBL17231644 | 0.83 | HPGD (0.58) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 | |
| SCHEMBL14479038 | 0.81 | DDAH1 (0.58) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 | |
| SCHEMBL14000501 | 0.80 | DDAH1 (0.61) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 | |
| SCHEMBL28901118 | 0.78 | DDAH1 (0.59) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 | |
| SCHEMBL12945871 | 0.78 | ADAM17 (0.45) | HSP90AA1TDP1ALDH1A1HTTMAPT | |
| SCHEMBL30831285 | 0.78 | SMN1; SMN2 (0.51) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 | |
| SCHEMBL3339259 | 0.77 | DDAH1 (0.61) | DDAH1HSP90AA1NPSR1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10226535-B2 | Auristatin compounds and conjugates thereof | MERSANA THERAPEUTICS, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| EP-2928503-B1 | CONJUGATES OF AURISTATIN COMPOUNDS | MERSANA THERAPEUTICS INC (US) | 2019-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10226535-B2 | Auristatin compounds and conjugates thereof | PBRM1, AURKB, ILK | DDAH1 1724/4885HSP90AA1 2489/4885NPSR1 3842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.