Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dapsone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.73 |
| ▸ | TSHR | P16473 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | MPO | P05164 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 5/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA1 | P00915 | 4/20 | 0.54 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.54 |
| ▸ | CA4 | P22748 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dapsone SCHEMBL26667340 | 0.91 | LMNA (0.83) | HTR6TSHRLMNACYP3A4MPO | |
| SCHEMBL29692583 | 0.91 | LMNA (0.83) | HTR6TSHRLMNACYP3A4MPO | |
| SCHEMBL34500 | 0.91 | LMNA (0.83) | HTR6TSHRLMNACYP3A4MPO | |
| SCHEMBL8721954 | 0.91 | LMNA (0.83) | HTR6TSHRLMNACYP3A4MPO | |
| SCHEMBL1100221 | 0.86 | LMNA (0.91) | HTR6TSHRLMNACYP3A4MPO | |
| SCHEMBL324582 | 0.86 | HTR6 (0.73) | HTR6TSHRLMNACYP3A4MPO | |
| Dapsone SCHEMBL27773927 | 0.85 | HTR6 (0.89) | HTR6TSHRLMNACYP3A4MPO | |
| Dapsone SCHEMBL1219599 | 0.85 | HTR6 (1.00) | HTR6TSHRLMNACYP3A4MPO | |
| SCHEMBL324893 | 0.85 | HTR6 (1.00) | HTR6TSHRLMNACYP3A4MPO | |
| Dapsone SCHEMBL5055312 | 0.85 | HTR6 (1.00) | HTR6TSHRLMNACYP3A4MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8248755-B2 | Polyimides and thin films, electronic articles and capacitors comprising these, and methods of making them | GENERAL ELECTRIC COMPANY (US) | 2012-08-21 | — | — | US | disclosed |
| US-20110267739-A1 | Polyimides and thin films, electronic articles and capacitors comprising these, and methods of making them | GENERAL ELECTRIC COMPANY (US) | 2011-11-03 | — | — | US | disclosed |