Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 4/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | ILK | Q13418 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939164 | 0.72 | GPR35 (0.45) | DYRK1ADYRK1BAKT1AKT2ROCK1 | |
| SCHEMBL28755646 | 0.72 | ERN1 (0.40) | ERN1DYRK1ADYRK1BCDC7DBF4 | |
| SCHEMBL16638963 | 0.71 | DYRK1A (0.42) | ERN1DYRK1ADYRK1BAKT1AKT2 | |
| SCHEMBL27605051 | 0.70 | DYRK1A (0.62) | ERN1DYRK1ADYRK1B | |
| SCHEMBL24226877 | 0.69 | AKT2 (0.55) | ERN1AKT1AKT2ROCK1MYLK4 | |
| SCHEMBL723278 | 0.69 | ALDH1A1 (0.44) | DYRK1ADYRK1B | |
| SCHEMBL940221 | 0.69 | DYRK1A (0.43) | ERN1DYRK1ADYRK1BROCK1GPR35 | |
| Hydrochloric Acid SCHEMBL22042397 | 0.68 | AKT2 (0.53) | ERN1AKT1AKT2ROCK1MYLK4 | |
| SCHEMBL24345956 | 0.68 | AKT1 (0.53) | ERN1DYRK1ADYRK1BAKT1AKT2 | |
| SCHEMBL24345957 | 0.68 | AKT1 (0.53) | ERN1DYRK1ADYRK1BAKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113980001-B | Pyrazolol-pyridazinone coupling compound, pharmaceutical composition thereof and application of pyrazolol-pyridazinone coupling compound in medicines | 贵州医科大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-113980001-A | Pyrazole alcohol-pyridazinone coupling compound, pharmaceutical composition thereof and application thereof in medicines | 贵州医科大学 | 2022-01-28 | — | — | CN | disclosed |
| CN-102947295-A | 3,3-disubstituted-(8-aza-bicyclo [3.2.1]oct-8-y)-[5-(1 -pyrazol-4-yl)-thiophe-3-yl] methanones as inhibitors of 11[beta]-HSD1 | UNIV EDINBURGH | 2013-02-27 | — | — | CN | disclosed |
| US-8299063-B2 | Amido-thiophene compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2012-10-30 | — | — | US | disclosed |
| US-20110015178-A1 | Amido-Thiophene Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015178-A1 | Amido-Thiophene Compounds and Their Use | HSD11B1, HSD11B2, HSD17B1 | ERN1 1272/4885DYRK1A 3405/4885DYRK1B 3449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.