Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14545893 | 0.83 | CDK2 (0.46) | SMN1; SMN2LMNAPKMKMT2AMEN1 | |
| SCHEMBL12954186 | 0.76 | HRH3 (0.41) | SMN1; SMN2TSHRHPGD | |
| SCHEMBL14613303 | 0.73 | HTT (0.41) | SMN1; SMN2LMNAKMT2AMEN1GAA | |
| SCHEMBL13120270 | 0.73 | CDK2 (0.59) | SMN1; SMN2LMNAPKM | |
| SCHEMBL12954198 | 0.73 | GSK3B (0.42) | KMT2AMEN1GAAPOLBHPGD | |
| SCHEMBL13288719 | 0.72 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAKMT2APOLBALOX15 | |
| SCHEMBL12954448 | 0.71 | HPGD (0.41) | SMN1; SMN2LMNAPKMKMT2AMEN1 | |
| SCHEMBL13288970 | 0.71 | CDK2 (0.45) | NPC1RAB9A | |
| SCHEMBL13288651 | 0.70 | — | — | |
| SCHEMBL14043329 | 0.70 | KISS1R (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |