Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120270 | 0.89 | CDK2 (0.59) | CDK2GSK3BSMN1; SMN2LMNAPKM | |
| SCHEMBL13288740 | 0.85 | GSK3B (0.46) | CDK2GSK3BLMNAALDH1A1POLB | |
| SCHEMBL13288970 | 0.85 | CDK2 (0.45) | CDK2GSK3B | |
| SCHEMBL13289269 | 0.85 | GSK3B (0.46) | CDK2GSK3BLMNAKMT2AMEN1 | |
| SCHEMBL13288875 | 0.85 | GSK3B (0.46) | CDK2GSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL14545832 | 0.84 | CDK2 (0.48) | CDK2GSK3BSMN1; SMN2MAPTLMNA | |
| SCHEMBL13120060 | 0.84 | CDK2 (0.58) | CDK2GSK3BSMN1; SMN2 | |
| SCHEMBL13289308 | 0.83 | CDK2 (0.53) | CDK2GSK3BSMN1; SMN2MAPTKMT2A | |
| SCHEMBL13288867 | 0.83 | CDK2 (0.47) | CDK2GSK3B | |
| SCHEMBL12954451 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAPKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |