Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 2/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1034964 | 0.83 | HSD17B2 (0.46) | CCR9 | |
| SCHEMBL1035106 | 0.72 | HSD17B2 (0.47) | CCR9 | |
| SCHEMBL12955953 | 0.72 | ALDH1A1 (0.39) | CCR9ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14313772 | 0.70 | MEN1 (0.34) | — | |
| SCHEMBL1035070 | 0.69 | HSD17B2 (0.47) | CCR9 | |
| SCHEMBL1076570 | 0.69 | HSD17B2 (0.43) | CCR9 | |
| Dimethylamine SCHEMBL1076568 | 0.69 | HSD17B2 (0.45) | CCR9 | |
| SCHEMBL1036740 | 0.69 | HSD17B2 (0.45) | CCR9 | |
| SCHEMBL1038561 | 0.69 | HSD17B2 (0.44) | CCR9 | |
| SCHEMBL1034935 | 0.68 | CCR9 (0.45) | CCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049515-B1 | TRIAZOLYL PYRIDYL BENZENESULFONAMIDES AS CCR2 OR CCR9 MODULATORS FOR THE TREATMENT OF ATHEROSCLEROSIS | CHEMOCENTRYX INC (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2008008375-A2 | TRIAZOLYL PYRIDYL BENZENESULFONAMIDES AS CCR2 OR CCR9 MODULATORS FOR THE TREATMENT OF INFLAMMATION | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |