Sugi Predict

Sugi Predict / Compounds / SCHEMBL1295751

SCHEMBL1295751

SCHEMBL1295751

CC(C)(C)OC(=O)NC/C(=C\Cl)CCc1ccc(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 1/20 0.48
▸ LMNA P02545 2/20 0.44
▸ PLAAT3 P53816 2/20 0.43
▸ PLAAT5 Q96KN8 2/20 0.43
▸ PLAAT2 Q9NWW9 2/20 0.43
▸ PLAAT4 Q9UL19 2/20 0.43
▸ DRD2 P14416 5/20 0.41
▸ CA1 P00915 1/20 0.40
▸ CA2 P00918 1/20 0.40
▸ PPARG P37231 1/20 0.39
▸ PPARA Q07869 1/20 0.39
▸ SIGMAR1 Q99720 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ ATM Q13315 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ PKM P14618 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ CYP1A2 P05177 1/20 0.38
▸ CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1295275 1.00 GAA (0.48) GAALMNAPLAAT3PLAAT5PLAAT2
SCHEMBL1295270 1.00 GAA (0.48) GAALMNAPLAAT3PLAAT5PLAAT2
SCHEMBL1296056 0.90 TDP1 (0.43) GAAPLAAT3PLAAT5PLAAT2PLAAT4
SCHEMBL1296052 0.90 TDP1 (0.43) GAAPLAAT3PLAAT5PLAAT2PLAAT4
SCHEMBL1294927 0.89 CTSS (0.45) GAAPLAAT3PLAAT5PLAAT2PLAAT4
SCHEMBL1294923 0.89 CTSS (0.45) GAAPLAAT3PLAAT5PLAAT2PLAAT4
SCHEMBL1295456 0.89 CTSS (0.45) GAAPLAAT3PLAAT5PLAAT2PLAAT4
SCHEMBL1295342 0.89 SIGMAR1 (0.50) CA1SIGMAR1ATM
SCHEMBL1295338 0.89 SIGMAR1 (0.50) CA1SIGMAR1ATM
SCHEMBL1295736 0.88 F2RL1 (0.48) GAAPLAAT3PLAAT5PLAAT2PLAAT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110269811-A1 INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES FASTRACK PHARMACEUTICALS, INC. 2011-11-03 — — US disclosed
US-20090203764-A1 INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES FASTRACK PHARMACEUTICALS, INC. 2009-08-13 — — US disclosed
US-20070293548-A1 Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases LA JOLLA PHARMACEUTICAL COMPANY 2007-12-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070293548-A1 Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases VCAM1, AOC3, AOC2 GAA 1702/4885LMNA 4139/4885PLAAT3 3148/4885
US-20110269811-A1 INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES VCAM1, AOC3, AOC2 GAA 1702/4885LMNA 4139/4885PLAAT3 3148/4885
US-20090203764-A1 INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES VCAM1, AOC3, AOC2 GAA 1702/4885LMNA 4139/4885PLAAT3 3148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.