Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.46 |
| ▸ | GSK3B | P49841 | 11/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877359 | 0.88 | DYRK1A (0.41) | DYRK1AGSK3BCLK2CLK3ACHE | |
| SCHEMBL14877312 | 0.85 | ROCK2 (0.40) | DYRK1AGSK3BJAK1 | |
| SCHEMBL14887133 | 0.82 | DYRK1A (0.51) | DYRK1AGSK3BCLK2CLK3ABL1 | |
| SCHEMBL14877266 | 0.81 | ALDH1A1 (0.39) | ABL1HPGDTSHR | |
| SCHEMBL12965665 | 0.81 | ROCK2 (0.39) | DYRK1AGSK3BCLK2CLK3ACHE | |
| SCHEMBL14877412 | 0.80 | MAP3K11 (0.41) | TSHRSMN1; SMN2 | |
| SCHEMBL12821547 | 0.80 | CCNT1 (0.42) | ACHEHTTJAK1 | |
| SCHEMBL12828793 | 0.79 | DYRK1A (0.44) | DYRK1AGSK3BCLK2CLK3ACHE | |
| SCHEMBL12966243 | 0.79 | CNR2 (0.35) | HPGD | |
| SCHEMBL12965670 | 0.77 | MET (0.40) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962382-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-05-08 | — | — | US | disclosed |
| WO-2012135631-A1 | SUBSTITUTED 5-(PYRAZIN-2-YL)-1H-PYRAZOLO [3, 4-B] PYRIDINE AND PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ARRIEN PHARMAEUTICALS LLC (US) | 2012-10-04 | — | — | WO | disclosed |