Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877266 | 0.92 | ALDH1A1 (0.39) | DRD3MAP3K11PDE1BNR3C1LSS | |
| SCHEMBL12966244 | 0.87 | MEN1 (0.42) | PDE1BNR3C1LSSALDH1A1HPGD | |
| SCHEMBL14877312 | 0.80 | ROCK2 (0.40) | CNR2MAP3K11PDE1BMETEGFR | |
| SCHEMBL12965645 | 0.79 | DYRK1A (0.46) | HPGD | |
| SCHEMBL14877412 | 0.79 | MAP3K11 (0.41) | MAP3K11PDE1BMETMAPTALDH1A1 | |
| SCHEMBL14877359 | 0.79 | DYRK1A (0.41) | CNR2MAP3K11PDE1BMETEGFR | |
| SCHEMBL12965670 | 0.76 | MET (0.40) | CNR2PDE1BNR3C1METMAPT | |
| SCHEMBL12965644 | 0.76 | MAP3K11 (0.42) | MAP3K11PDE1BMET | |
| SCHEMBL12965665 | 0.76 | ROCK2 (0.39) | CNR2DRD3MAP3K11MAPTEGFR | |
| SCHEMBL14877256 | 0.75 | MAP3K11 (0.40) | MAP3K11PDE1BMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012135631-A1 | SUBSTITUTED 5-(PYRAZIN-2-YL)-1H-PYRAZOLO [3, 4-B] PYRIDINE AND PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ARRIEN PHARMAEUTICALS LLC (US) | 2012-10-04 | — | — | WO | disclosed |