Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473251 | 0.92 | ADRB2 (0.49) | KDM4EADRB2HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL18071741 | 0.84 | HTR7 (0.46) | KDM4EADRB2HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL10706756 | 0.83 | ADRB2 (0.65) | KDM4ECYP1A2CYP2C9CYP2C19CYP19A1 | |
| SCHEMBL12968482 | 0.83 | CYP1A2 (0.50) | KDM4ECYP1A2CYP2C9CYP2C19CYP19A1 | |
| SCHEMBL12967984 | 0.82 | SYK (0.55) | KDM4ECYP1A2CYP2C9CYP2C19CYP19A1 | |
| SCHEMBL12958317 | 0.82 | IDO1 (0.49) | KDM4EADRB2HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL34465293 | 0.78 | ADRB2 (0.63) | KDM4EADRB2HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL7638760 | 0.78 | ADRB2 (0.63) | KDM4EADRB2HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL11146857 | 0.78 | ADRA2A (0.49) | HTR7ALDH1A1SMN1; SMN2RAB9ATP53 | |
| SCHEMBL29997368 | 0.78 | KDM4E (0.51) | KDM4ECYP1A2CYP2C9CYP2C19CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120252758-A1 | Novel Bicyclic Pyridinones | PFIZER INC. | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252758-A1 | Novel Bicyclic Pyridinones | CYP2B6, CYP2C19, CYP2D6 | KDM4E 2745/4885CYP1A2 48/4885CYP2C9 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.