Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473213 | 0.92 | ADRB2 (0.48) | CYP1A2CYP2C19CYP2C9CYP19A1KDM4E | |
| SCHEMBL18071656 | 0.83 | TP53 (0.45) | ADRB2HTR7FYNTP53MAPK1 | |
| SCHEMBL12967950 | 0.83 | KDM4E (0.49) | CYP1A2CYP2C19CYP2C9CYP19A1KDM4E | |
| SCHEMBL12221501 | 0.83 | CYP11B1 (0.40) | CYP1A2CYP2C19CYP2C9CYP19A1 | |
| SCHEMBL12958354 | 0.82 | IDO1 (0.48) | ADRB2HTR7FYNTP53MAPK1 | |
| SCHEMBL10706756 | 0.82 | ADRB2 (0.65) | CYP1A2CYP2C19CYP2C9CYP19A1KDM4E | |
| SCHEMBL28460740 | 0.82 | FYN (0.43) | KDM4EADRB2L3MBTL1HTR7FYN | |
| SCHEMBL12191925 | 0.79 | PPARG (0.38) | CYP1A2CYP2C19CYP2C9CYP19A1 | |
| SCHEMBL29997103 | 0.78 | KDM4E (0.53) | CYP1A2CYP2C19CYP2C9CYP19A1KDM4E | |
| SCHEMBL28459155 | 0.77 | HTR7 (0.44) | KDM4EL3MBTL1HTR7ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120252758-A1 | Novel Bicyclic Pyridinones | PFIZER INC. | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252758-A1 | Novel Bicyclic Pyridinones | CYP2B6, CYP2C19, CYP2D6 | CYP1A2 48/4885CYP2C19 2/4885CYP2C9 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.