Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | MGLL | Q99685 | 2/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GABRD | O14764 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | UBE2M | P61081 | 1/20 | 0.53 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.53 |
| ▸ | GPR183 | P32249 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12569639 | 0.92 | HTT (0.59) | HPGDMGLLHSD11B1EPHX2HTT | |
| SCHEMBL18377903 | 0.85 | HPGD (0.59) | HPGDMGLLHSD11B1EPHX2HTT | |
| SCHEMBL1196861 | 0.84 | HPGD (0.54) | HPGDMGLLHSD11B1L3MBTL1MEN1 | |
| SCHEMBL18082577 | 0.84 | HPGD (0.62) | HPGDMGLLHSD11B1EPHX2HTT | |
| SCHEMBL12977 | 0.84 | HPGD (0.69) | HPGDMGLLHSD11B1EPHX2HTT | |
| SCHEMBL8054515 | 0.84 | HPGD (0.69) | HPGDMGLLHSD11B1EPHX2HTT | |
| SCHEMBL27748883 | 0.83 | ACHE (0.68) | HPGDMGLLL3MBTL1MEN1KMT2A | |
| SCHEMBL14238822 | 0.83 | HPGD (0.83) | HPGDMGLLHSD11B1HTTL3MBTL1 | |
| SCHEMBL7130857 | 0.83 | HPGD (0.83) | HPGDMGLLHSD11B1HTTL3MBTL1 | |
| SCHEMBL23417312 | 0.82 | HPGD (0.68) | HPGDMGLLHSD11B1EPHX2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |