Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11632860 | 0.90 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AHPGDHTTMEN1 | |
| SCHEMBL18112724 | 0.81 | GRIK1 (0.51) | — | |
| SCHEMBL2432245 | 0.80 | NPC1 (0.73) | SMN1; SMN2KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL3403500 | 0.79 | CNR2 (0.52) | SMN1; SMN2KMT2AHPGDHTTMEN1 | |
| SCHEMBL24814118 | 0.79 | MMP1 (0.57) | KMT2ACYP2C9CYP2C19CYP2D6 | |
| SCHEMBL7598869 | 0.78 | TSHR (0.51) | SMN1; SMN2KMT2AHPGDALDH1A1CYP2C9 | |
| SCHEMBL27962256 | 0.78 | CTSK (0.56) | SMN1; SMN2KMT2AHPGDHTTMEN1 | |
| SCHEMBL6996053 | 0.78 | SIGMAR1 (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL2543476 | 0.76 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2AHPGDHTTMEN1 | |
| SCHEMBL25139695 | 0.76 | CYP2D6 (0.56) | SMN1; SMN2KMT2ACYP2C9CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694067-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | Æterna Zentaris GmbH (DE) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012136691-A1 | PYRIDOPYRAZINE DERIVATIVES AND THEIR USE | ÆTERNA ZENTARIS GMBH (DE) | 2012-10-11 | — | — | WO | disclosed |