Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10396064 | 0.88 | ALDH1A1 (0.54) | SIGMAR1MAOAPTGS1MEN1KMT2A | |
| SCHEMBL15907606 | 0.82 | SIGMAR1 (0.59) | SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL6998336 | 0.79 | AOC3 (0.46) | SIGMAR1KMT2ALMNACYP2D6CYP2C9 | |
| SCHEMBL3712834 | 0.78 | SLC6A2 (0.56) | SIGMAR1MAOASLC6A2MAOBAOC3 | |
| SCHEMBL12986367 | 0.78 | SMN1; SMN2 (0.56) | MEN1KMT2ANPC1ALDH1A1CYP1A2 | |
| SCHEMBL108633 | 0.77 | LMNA (0.54) | SIGMAR1L3MBTL1LMNAAOC3 | |
| SCHEMBL19090603 | 0.77 | SIGMAR1 (0.50) | SIGMAR1MAOAL3MBTL1MEN1KMT2A | |
| SCHEMBL11132051 | 0.77 | SIGMAR1 (0.64) | SIGMAR1LMNACYP1A2CYP3A4HTR1A | |
| Bromide SCHEMBL14833545 | 0.76 | SLC6A2 (0.54) | SIGMAR1MAOASLC6A2MAOBAOC3 | |
| Pheniprazine SCHEMBL163709 | 0.75 | SIGMAR1 (0.65) | SIGMAR1MAOAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151155-C | 1, 5-dihydro-pyrazolo [3, 4-D ] -pyrimidone derivatives | — | 2004-05-26 | — | — | CN | disclosed |
| EP-0973774-B1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| US-6174884-B1 | CARDIOVASCULAR DISORDERS; CEREBROVASCULAR DISEASES; VASCULAR SYSTEM DISORDERS, ESPECIALLY THE PERIPHERAL BLOOD VESSELS; UROGENITAL DISORDERS; HYPOTENSIVE AGENTS; ANTIARRYTHMIA AND -ISCHEMIC AGENTS; PHOSPHODIESTERASE ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2001-01-16 | — | — | US | disclosed |
| CN-1255133-A | 1,5-dihydro-pyrazolo [3,4-D]-pyrimidinone derivatives | BAYER AG (DE) | 2000-05-31 | — | — | CN | disclosed |
| EP-0973774-A1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040384-A1 | 1,5-DIHYDRO-PYRAZOLO[3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |