Sugi Predict

Sugi Predict / Compounds / SCHEMBL129879

SCHEMBL129879

SCHEMBL129879

COc1cc(Cl)cc(-c2nn(C)c3ncnc(N)c23)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 15/20 0.57
▸ SRC P12931 15/20 0.57
▸ PIK3CA P42336 14/20 0.57
▸ PIK3CB P42338 14/20 0.57
▸ PIK3CG P48736 14/20 0.57
▸ PRKDC P78527 14/20 0.57
▸ ABL1 P00519 14/20 0.57
▸ HCK P08631 13/20 0.57
▸ EGFR P00533 12/20 0.57
▸ MTOR P42345 12/20 0.57
▸ EPHB4 P54760 12/20 0.57
▸ PI4KB Q9UBF8 5/20 0.57
▸ KDR P35968 11/20 0.55
▸ NUDT14 O95848 1/20 0.54
▸ NUDT5 Q9UKK9 1/20 0.54
▸ BTK Q06187 1/20 0.48
▸ FGFR1 P11362 1/20 0.47
▸ FGFR2 P21802 1/20 0.47
▸ FGFR4 P22455 1/20 0.47
▸ FGFR3 P22607 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL129505 0.91 PIK3CD (0.62) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL24156822 0.86 PIK3CD (0.52) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL130486 0.85 PIK3CD (0.63) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL11807 0.82 PIK3CD (0.60) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL130590 0.81 SRC (0.73) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL130752 0.81 NUDT14 (0.74) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL12192 0.81 PIK3CD (0.53) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL128507 0.79 SRC (0.60) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL129615 0.78 SRC (0.79) PIK3CDSRCPIK3CAPIK3CBPIK3CG
SCHEMBL13019672 0.78 SRC (0.69) PIK3CDSRCPIK3CAPIK3CBPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 — — US disclosed
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 — — US disclosed
US-20190282581-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2019-09-19 — — US disclosed
US-20180110783-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS SA (CH) 2018-04-26 — — US disclosed
US-9775841-B2 Compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2017-10-03 — — US disclosed
US-20160318890-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2016-11-03 — — US disclosed
US-9421209-B2 Kinase modulators RHIZEN PHARMACEUTICALS SA (CH) 2016-08-23 — — US disclosed
US-20150320752-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2015-11-12 — — US disclosed
US-20150174131-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2015-06-25 — — US disclosed
US-9018375-B2 Substituted chromenes as kinase modulators RHIZEN PHARMACEUTICALS SA (CH) 2015-04-28 — — US disclosed
US-20140080827-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS SA (CH) 2014-03-20 — — US disclosed
US-8642607-B2 4H-chromen-4-one compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2014-02-04 — — US disclosed
US-20120289496-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS SA (CH) 2012-11-15 — — US disclosed
US-20120059001-A1 NOVEL KINASE MODULATORS INCOZEN THERAPEUTICS PVT. LTD. (IN) 2012-03-08 — — US disclosed
US-20110118257-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS SA (CH) 2011-05-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150174131-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CD 70/4885SRC 314/4885PIK3CA 143/4885
US-20150320752-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PIK3CD 47/4885SRC 285/4885PIK3CA 88/4885
US-20120289496-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PIK3CD 47/4885SRC 285/4885PIK3CA 88/4885
US-20180110783-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PIK3CD 47/4885SRC 285/4885PIK3CA 88/4885
US-20140080827-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CD 70/4885SRC 314/4885PIK3CA 143/4885
US-20190282581-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PIK3CD 47/4885SRC 285/4885PIK3CA 88/4885
US-20110118257-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CD 70/4885SRC 314/4885PIK3CA 143/4885
US-11858907-B2 Kinase modulators RPS6KA1, RPS6KA2, PRKAR2A PIK3CD 103/4885SRC 110/4885PIK3CA 144/4885
US-20160318890-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CD 70/4885SRC 314/4885PIK3CA 143/4885
US-20120059001-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB PIK3CD 70/4885SRC 314/4885PIK3CA 143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.