Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | EBP | Q15125 | 2/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1299253 | 0.99 | SIGMAR1 (0.68) | SIGMAR1HTR1AEBPTMEM97ALDH1A1 | |
| SCHEMBL16024760 | 0.87 | SLC6A3 (0.66) | SIGMAR1HTR1AALDH1A1 | |
| SCHEMBL1298736 | 0.87 | SIGMAR1 (0.67) | SIGMAR1EBP | |
| Hydrochloric Acid SCHEMBL1299589 | 0.86 | SIGMAR1 (0.65) | SIGMAR1 | |
| SCHEMBL5695484 | 0.84 | SIGMAR1 (0.63) | SIGMAR1HTR1ATMEM97ALDH1A1CYP1A2 | |
| SCHEMBL18164595 | 0.83 | SIGMAR1 (0.61) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3454609 | 0.82 | SIGMAR1 (1.00) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11383498 | 0.82 | TAAR1 (0.65) | SIGMAR1HTR1ATMEM97CYP1A2CYP3A4 | |
| SCHEMBL9378627 | 0.82 | SIGMAR1 (1.00) | SIGMAR1HTR1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1332739 | 0.82 | KDM4E (0.67) | SIGMAR1HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269775-A1 | Piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-03 | — | — | US | claimed |
| US-20110269775-A1 | Piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-03 | — | — | US | disclosed |
| US-20110218205-A1 | Piperazine derivatives | M'S SCIENCE CORP. | 2011-09-08 | — | — | US | disclosed |
| US-7985751-B2 | Piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2011-07-26 | — | — | US | disclosed |
| US-7985751-B2 | Piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2011-07-26 | — | — | US | disclosed |
| US-20090143395-A1 | Piperazine Derivatives | SUN CONNIE L | 2009-06-04 | — | — | US | disclosed |
| US-20090143395-A1 | Piperazine Derivatives | SUN CONNIE L | 2009-06-04 | — | — | US | disclosed |
| WO-2007021545-A2 | PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269775-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRL1 | SIGMAR1 1/4885HTR1A 75/4885EBP 1084/4885 |
| US-20090143395-A1 | Piperazine Derivatives | SIGMAR1, OPRK1, OPRL1 | SIGMAR1 1/4885HTR1A 75/4885EBP 1084/4885 |
| US-20110218205-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRM1 | SIGMAR1 1/4885HTR1A 72/4885EBP 1385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.