Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.36 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.36 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromobenzene SCHEMBL14795351 | 0.97 | ALDH1A1 (0.58) | ALDH1A1TDP1MAPK1LMNACRHBP | |
| Bromobenzene SCHEMBL17609144 | 0.87 | ALDH1A1 (0.65) | ALDH1A1TDP1MAPK1LMNACRHBP | |
| Bromobenzene SCHEMBL28202175 | 0.85 | ALDH1A1 (0.44) | ALDH1A1TDP1MAPK1LMNASMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL28059145 | 0.84 | ALDH1A1 (0.65) | ALDH1A1TDP1MAPK1SMN1; SMN2MGLL | |
| Bromobenzene SCHEMBL27149738 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TDP1MAPK1LMNASMN1; SMN2 | |
| Bromobenzene SCHEMBL704553 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TDP1MAPK1LMNASMN1; SMN2 | |
| Bromobenzene SCHEMBL29291356 | 0.82 | ALDH1A1 (0.41) | ALDH1A1TDP1MAPK1LMNASMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL28193777 | 0.80 | HTT (0.43) | ALDH1A1TDP1MAPK1LMNASMN1; SMN2 | |
| Bromobenzene SCHEMBL28753154 | 0.78 | ALDH1A1 (0.79) | ALDH1A1TDP1MAPK1SMN1; SMN2MAPT | |
| Bromobenzene SCHEMBL29116318 | 0.78 | ALDH1A1 (0.92) | ALDH1A1TDP1MAPK1SMN1; SMN2ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450319-B2 | Pyrrolopyridazinone compound | UBE INDUSTRIES, LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| EP-1982986-B1 | PYRROLOPYRIDAZINONE COMPOUND AS PDE4 INHIBITOR | UBE INDUSTRIES (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20090036453-A1 | Pyrrolopyridazinone Compound | UBE INDUSTRIES, LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1982986-A1 | PYRROLOPYRIDAZINONE COMPOUND | Ube Industries, Ltd. (JP) | 2008-10-22 | — | — | EP | disclosed |
| CN-1283612-C | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative | SANKIO CHEMICAL CO LTD (JP) | 2006-11-08 | — | — | CN | disclosed |
| CN-1653030-A | Method for producing 4-phenyl-4-oxo-2-butenoate derivative | SANKIO CHEMICAL CO LTD (JP) | 2005-08-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036453-A1 | Pyrrolopyridazinone Compound | CBR3, CBR1, CYC1 | ALDH1A1 580/4885TDP1 4125/4885MAPK1 3503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.