Ademetionine

Ademetionine

SCHEMBL1300205

C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 5/20 1.00
PCMT1 P22061 3/20 1.00
PRMT5 O14744 3/20 1.00
PRMT1 Q99873 3/20 1.00
NSD3 Q9BZ95 2/20 1.00
PRMT3 O60678 2/20 1.00
PNMT P11086 2/20 1.00
PRMT6 Q96LA8 2/20 1.00
WDR77 Q9BQA1 2/20 1.00
PRMT7 Q9NVM4 2/20 1.00
ADORA3 P0DMS8 1/20 1.00
KDR P35968 1/20 1.00
PRMT8 Q9NR22 1/20 1.00
AMD1 P17707 5/20 0.87
NNMT P40261 3/20 0.62
DOT1L Q8TEK3 4/20 0.61
EHMT2 Q96KQ7 4/20 0.61
NSD2 O96028 3/20 0.61
SETD7 Q8WTS6 3/20 0.61
TRDMT1 O14717 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ademetionine SCHEMBL29355793 1.00 CARM1 (1.00) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL25176 1.00 CARM1 (1.00) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL1300198 1.00 CARM1 (1.00) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL1980696 0.99 CARM1 (0.98) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL4747876 0.99 CARM1 (0.98) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL3208346 0.94 CARM1 (0.89) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL29421543 0.94 CARM1 (0.89) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL5465751 0.94 CARM1 (0.88) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL7192080 0.93 CARM1 (0.93) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL3229444 0.93 CARM1 (0.86) CARM1PCMT1PRMT5PRMT1NSD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170340742-A1 A METHOD FOR DELIVERING A SUBSTANCE INTO CELLS Technische Universität Darmstadt (DE) 2017-11-30 US disclosed
US-9023636-B2 Microorganisms and methods for the biosynthesis of propylene GENOMATICA, INC. (US) 2015-05-05 US disclosed
US-8617862-B2 Microorganisms for producing propylene and methods related thereto GENOMATICA, INC. (US) 2013-12-31 US disclosed
EP-2563926-A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF PROPYLENE Genomatica, Inc. (US) 2013-03-06 EP disclosed
US-20120329119-A1 MICROORGANISMS FOR PRODUCING PROPYLENE AND METHODS RELATED THERETO GENOMATICA, INC. 2012-12-27 US disclosed
WO-2011137198-A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF PROPYLENE GENOMATICA, INC. (US) 2011-11-03 WO disclosed
US-20110269204-A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF PROPYLENE AGAIN BIO APS (DK) 2011-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170340742-A1 A METHOD FOR DELIVERING A SUBSTANCE INTO CELLS CD44, TACR1, SELP CARM1 3439/4885PCMT1 1943/4885PRMT5 2465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.