Ademetionine

Ademetionine

SCHEMBL4747876

C[S+](CCC(N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O.Cl

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Ademetionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR known ✓ P35968 1/20 0.98
CARM1 Q86X55 5/20 0.98
PCMT1 P22061 3/20 0.98
PRMT5 O14744 3/20 0.98
PRMT1 Q99873 3/20 0.98
NSD3 Q9BZ95 2/20 0.98
PRMT3 O60678 2/20 0.98
PNMT P11086 2/20 0.98
PRMT6 Q96LA8 2/20 0.98
WDR77 Q9BQA1 2/20 0.98
PRMT7 Q9NVM4 2/20 0.98
ADORA3 P0DMS8 1/20 0.98
PRMT8 Q9NR22 1/20 0.98
AMD1 P17707 5/20 0.85
NNMT P40261 3/20 0.61
DOT1L Q8TEK3 4/20 0.60
EHMT2 Q96KQ7 4/20 0.60
NSD2 O96028 3/20 0.60
SETD7 Q8WTS6 3/20 0.60
TRDMT1 O14717 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ademetionine SCHEMBL25176 0.99 CARM1 (1.00) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL1300198 0.99 CARM1 (1.00) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL1300205 0.99 CARM1 (1.00) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL29355793 0.99 CARM1 (1.00) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL1980696 0.98 CARM1 (0.98) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL3208346 0.94 CARM1 (0.89) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL29421543 0.93 CARM1 (0.89) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL29986218 0.93 CARM1 (0.98) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL5465751 0.93 CARM1 (0.88) CARM1PCMT1PRMT5PRMT1NSD3
Ademetionine SCHEMBL7192080 0.92 CARM1 (0.93) CARM1PCMT1PRMT5PRMT1NSD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240218351-A1 SINGLE STRANDED RNA PURIFICATION METHODS NOVO NORDISK A/S (DK) 2024-07-04 US disclosed
CN-117730149-A Single-stranded RNA purification method 2赛文缇生物公司 2024-03-19 CN disclosed
US-20140227318-A1 SLEEP QUALITY IMPROVING AGENT LION CORPORATION (JP) 2014-08-14 US disclosed
EP-2764869-A1 AGENT FOR IMPROVING QUALITY OF SLEEP Lion Corporation (JP) 2014-08-13 EP disclosed
CN-103841985-A Agent for improving quality of sleep LION CORP 2014-06-04 CN disclosed
WO-2008107711-A1 PARTIALLY-METHYLATED BREAK LIGHT ASSAY FOR DNA METHYLTRANSFERASE ACTIVITY UNIVERSITY OF SOUTHAMPTON (GB) 2008-09-12 WO disclosed
US-6635615-B1 Stable salts of S-adenosyl-l-methionine HEBERT SAM-E LLC 2003-10-21 US disclosed