Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.37 |
| ▸ | PTGFR | P43088 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382787 | 0.87 | CFD (0.40) | CFDPTGFRHSD11B1KCNK3 | |
| SCHEMBL13005180 | 0.83 | GPR119 (0.38) | CFDPTGFRLMNA | |
| SCHEMBL13005135 | 0.78 | PTGFR (0.58) | PTGFRHSD11B1ALDH1A1 | |
| SCHEMBL7047521 | 0.78 | PTGFR (0.58) | PTGFRHSD11B1ALDH1A1 | |
| SCHEMBL3383792 | 0.78 | PTGFR (0.58) | PTGFRHSD11B1ALDH1A1 | |
| SCHEMBL7045396 | 0.71 | PRKACA (0.40) | CFDPTGFRROCK2ROCK1 | |
| SCHEMBL3383580 | 0.71 | PRKACA (0.40) | CFDPTGFRROCK2ROCK1 | |
| SCHEMBL3386255 | 0.71 | PTGFR (0.46) | CFDPTGFRKCNK3 | |
| SCHEMBL28252012 | 0.71 | PTGFR (0.44) | PTGFRKCNK3 | |
| SCHEMBL3383891 | 0.69 | JAK2 (0.38) | CFDPTGFRKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487442-B1 | THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR | MERCK SERONO SA (CH) | 2010-12-01 | — | — | EP | disclosed |