Sugi Predict

Sugi Predict / Compounds / SCHEMBL13005294

SCHEMBL13005294

SCHEMBL13005294

COC(=O)c1cc2cc(-c3ccc(O)cc3)ccc2c2c1C=CC(c1ccccc1)(c1ccc(C3CCCCC3)cc1)O2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 1/20 0.35
▸ SLC6A2 P23975 1/20 0.34
▸ SLC6A4 P31645 1/20 0.34
▸ KDM4E B2RXH2 3/20 0.33
▸ HSD17B10 Q99714 2/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ HPGD P15428 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ DGAT1 O75907 3/20 0.33
▸ CYP3A4 P08684 2/20 0.31
▸ TSHR P16473 1/20 0.31
▸ RECQL P46063 1/20 0.31
▸ DEGS1 O15121 1/20 0.31
▸ KMT2A Q03164 3/20 0.31
▸ SOAT2 O75908 1/20 0.31
▸ P2RY14 Q15391 2/20 0.31
▸ MEN1 O00255 2/20 0.30
▸ CTSD P07339 1/20 0.30
▸ NR4A2 P43354 1/20 0.30
▸ LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13005293 0.90 ALDH1A1 (0.33) DHODHSLC6A2SLC6A4KDM4EALDH1A1
SCHEMBL13005295 0.88 MAPK8 (0.36) DHODHKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL13005291 0.85 ALDH1A1 (0.33) ALDH1A1HPGDNPSR1DGAT1CYP3A4
SCHEMBL18971681 0.82 SIRT2 (0.34) DHODHKDM4EALDH1A1HPGDNPSR1
SCHEMBL15693690 0.80 DHODH (0.35) DHODHKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL15277650 0.80 SLC6A4 (0.36) DHODHSLC6A2SLC6A4ALDH1A1NPSR1
SCHEMBL15693594 0.79 NR4A2 (0.34) DHODHKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL16479409 0.78 ESR1 (0.34) DHODHKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL5107478 0.77 NR4A2 (0.37) KDM4EALDH1A1HPGDNPSR1TSHR
SCHEMBL18971678 0.76 P2RY14 (0.33) P2RY14ADRB3HTR1BHTR2AHRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9102652-B2 Dichroic-photochromic 2H-naphtho[1,2-b]pyran compounds and devices ALPHAMICRON INCORPORATED (US) 2015-08-11 — — US disclosed
US-9102652-B2 Dichroic-photochromic 2H-naphtho[1,2-b]pyran compounds and devices ALPHAMICRON INCORPORATED (US) 2015-08-11 — — US disclosed
US-20140197361-A1 DICHROIC-PHOTOCHROMIC 2H-NAPHTHO[1,2-b]PYRAN COMPOUNDS AND DEVICES ALPHAMICRON INCORPORATED (US) 2014-07-17 — — US disclosed
US-20140197361-A1 DICHROIC-PHOTOCHROMIC 2H-NAPHTHO[1,2-b]PYRAN COMPOUNDS AND DEVICES ALPHAMICRON INCORPORATED (US) 2014-07-17 — — US disclosed
US-20100324296-A1 DICHROIC-PHOTOCHROMIC COMPOUNDS AND DEVICES ALPHAMICRON INCORPORATED 2010-12-23 — — US disclosed
US-20100324296-A1 DICHROIC-PHOTOCHROMIC COMPOUNDS AND DEVICES ALPHAMICRON INCORPORATED 2010-12-23 — — US disclosed
WO-2008051420-A2 DICHROIC-PHOTOCHROMIC COMPOUNDS AND DEVICES ALPHAMICRON, INC. (US) 2008-05-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140197361-A1 DICHROIC-PHOTOCHROMIC 2H-NAPHTHO[1,2-b]PYRAN COMPOUNDS AND DEVICES NR0B2, NR0B1, DHCR24 DHODH 606/4885SLC6A2 2185/4885SLC6A4 2086/4885
US-20100324296-A1 DICHROIC-PHOTOCHROMIC COMPOUNDS AND DEVICES NR0B2, NR0B1, NR2E3 DHODH 957/4885SLC6A2 2688/4885SLC6A4 2291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.