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SCHEMBL13005295

SCHEMBL13005295

COC(=O)c1cc2cc(Br)ccc2c2c1C=CC(c1ccccc1)(c1ccc(C3CCCCC3)cc1)O2

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MAPK8 P45983 1/20 0.36
▸ DHODH Q02127 1/20 0.33
▸ CYP3A4 P08684 3/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ L3MBTL1 Q9Y468 2/20 0.32
▸ CHEK1 O14757 1/20 0.31
▸ ALDH1A1 P00352 3/20 0.31
▸ GAA P10253 1/20 0.31
▸ TACR3 P29371 1/20 0.31
▸ KDM4E B2RXH2 2/20 0.31
▸ HSD17B10 Q99714 2/20 0.31
▸ RAB9A P51151 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ RECQL P46063 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31
▸ MEN1 O00255 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ NAAA Q02083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13005294 0.88 DHODH (0.35) DHODHCYP3A4KMT2AALDH1A1GAA
SCHEMBL13005293 0.85 ALDH1A1 (0.33) DHODHCYP3A4KMT2AALDH1A1KDM4E
SCHEMBL13005291 0.80 ALDH1A1 (0.33) CYP3A4KMT2AALDH1A1TSHRHPGD
SCHEMBL5107478 0.78 NR4A2 (0.37) KMT2AALDH1A1GAAKDM4ETSHR
SCHEMBL26290022 0.78 KDM4E (0.45) KMT2AALDH1A1GAAKDM4EHSD17B10
SCHEMBL3238390 0.78 PLA2G2A (0.39) DHODHKMT2AALDH1A1GAAKDM4E
SCHEMBL4798246 0.78 PLA2G2A (0.41) KMT2AALDH1A1KDM4EHSD17B10RAB9A
SCHEMBL18961301 0.77 ALDH1A1 (0.36) KMT2AL3MBTL1ALDH1A1GAAKDM4E
SCHEMBL6653085 0.77 KMT2A (0.39) KMT2AL3MBTL1ALDH1A1KDM4ERAB9A
SCHEMBL6650438 0.76 MEN1 (0.41) KMT2AL3MBTL1ALDH1A1KDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9102652-B2 Dichroic-photochromic 2H-naphtho[1,2-b]pyran compounds and devices ALPHAMICRON INCORPORATED (US) 2015-08-11 — — US disclosed
US-9102652-B2 Dichroic-photochromic 2H-naphtho[1,2-b]pyran compounds and devices ALPHAMICRON INCORPORATED (US) 2015-08-11 — — US disclosed
US-20140197361-A1 DICHROIC-PHOTOCHROMIC 2H-NAPHTHO[1,2-b]PYRAN COMPOUNDS AND DEVICES ALPHAMICRON INCORPORATED (US) 2014-07-17 — — US disclosed
US-20140197361-A1 DICHROIC-PHOTOCHROMIC 2H-NAPHTHO[1,2-b]PYRAN COMPOUNDS AND DEVICES ALPHAMICRON INCORPORATED (US) 2014-07-17 — — US disclosed
US-20100324296-A1 DICHROIC-PHOTOCHROMIC COMPOUNDS AND DEVICES ALPHAMICRON INCORPORATED 2010-12-23 — — US disclosed
US-20100324296-A1 DICHROIC-PHOTOCHROMIC COMPOUNDS AND DEVICES ALPHAMICRON INCORPORATED 2010-12-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140197361-A1 DICHROIC-PHOTOCHROMIC 2H-NAPHTHO[1,2-b]PYRAN COMPOUNDS AND DEVICES NR0B2, NR0B1, DHCR24 MAPK8 3876/4885DHODH 606/4885CYP3A4 967/4885
US-20100324296-A1 DICHROIC-PHOTOCHROMIC COMPOUNDS AND DEVICES NR0B2, NR0B1, NR2E3 MAPK8 3978/4885DHODH 957/4885CYP3A4 819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.