Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005476 | 0.86 | HSD17B2 (0.51) | ALDH1A1MAPTAOC3BCL2HSD17B2 | |
| SCHEMBL13060799 | 0.86 | HPGD (0.69) | HPGDALDH1A1MAPTAOC3LMNA | |
| SCHEMBL4444933 | 0.77 | HPGD (1.00) | HPGDALDH1A1MAPTAOC3LMNA | |
| SCHEMBL7556594 | 0.76 | PPARG (0.59) | HPGDALDH1A1MAPTAOC3LMNA | |
| SCHEMBL11364742 | 0.76 | AOC3 (1.00) | AOC3 | |
| SCHEMBL8636391 | 0.76 | MEN1 (0.46) | MAPTBCL2PTGS2 | |
| SCHEMBL28161128 | 0.75 | CTSS (0.48) | PTGS2 | |
| SCHEMBL1513819 | 0.75 | MMP3 (0.56) | HSD17B2HSD17B1PTGS2 | |
| SCHEMBL4316686 | 0.74 | AGXT (0.50) | AOC3BCL2PTGESPTGS2 | |
| SCHEMBL23710191 | 0.74 | BCL2 (0.48) | ALDH1A1MAPTLMNABCL2PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |