Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 5/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 6/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005458 | 0.86 | HPGD (0.61) | HSD17B2HSD17B1BCL2AOC3PTGES | |
| SCHEMBL23514718 | 0.86 | ERN1 (0.52) | HSD17B2HSD17B1ERN1 | |
| SCHEMBL13060851 | 0.84 | BCL2 (0.69) | HSD17B2HSD17B1BCL2AOC3ERN1 | |
| SCHEMBL10160068 | 0.83 | KMT2A (0.49) | HSD17B2HSD17B1ERN1 | |
| SCHEMBL8180284 | 0.80 | ACACB (0.56) | PTGS2ALDH1A1 | |
| SCHEMBL13005470 | 0.78 | ERN1 (0.47) | ERN1ALDH1A1 | |
| SCHEMBL13680801 | 0.78 | ERN1 (0.50) | HSD17B2HSD17B1BCL2AOC3ERN1 | |
| SCHEMBL8636391 | 0.78 | MEN1 (0.46) | BCL2PTGS2MAPTCTSSCTSK | |
| SCHEMBL28161128 | 0.78 | CTSS (0.48) | PTGS2CTSSCTSK | |
| SCHEMBL1513819 | 0.77 | MMP3 (0.56) | HSD17B2HSD17B1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |