Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061016 | 0.89 | TSHR (0.40) | TSHRADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL13005487 | 0.82 | CETP (0.40) | TSHRCETPALOX5ADRA2BADRA2C | |
| SCHEMBL13005484 | 0.82 | OPRK1 (0.47) | CETPALOX5ADRA2BADRA2CSLC6A2 | |
| SCHEMBL13005495 | 0.81 | OPRK1 (0.43) | TSHRCETPALOX5ADRA2BADRA2C | |
| SCHEMBL13005494 | 0.79 | ALOX5 (0.41) | CETPALOX5HPGD | |
| SCHEMBL13005518 | 0.74 | CETP (0.40) | TSHRCETPALOX5ADRA2BADRA2C | |
| SCHEMBL13005557 | 0.72 | SIGMAR1 (0.41) | TSHRCETPALOX5ADRA2BADRA2C | |
| SCHEMBL13005605 | 0.72 | SLC6A2 (0.45) | TSHRCETPALOX5ADRA2BADRA2C | |
| SCHEMBL13060671 | 0.72 | OPRK1 (0.39) | TSHRADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL16640979 | 0.72 | ALDH1A1 (0.50) | TSHRCETPADRA2BADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |